LivoBot Co., Ltd.
Platform for High-Throughput Screening

Platform for High-Throughput Screening

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High-Throughput Screening Solution

LivoBot integrates automated liquid handling with intelligent process control to deliver a complete high-throughput screening automation solution. Covering the full workflow—from plasmid extraction and purification to gene assembly, identification, and validation—it helps researchers and industrial users break through throughput limitations, eliminate human error, and accelerate R&D timelines.

 


1. LivoBot's Instrument Matrix – Creating an "Intelligent Closed Loop"


High Throughput Screening Solution

High Throughput Screening Solution

High Throughput Screening Solution

Biomolecule Purification System TGuide LP12HT Liquid-handling Workstation EosBot® LH96Benchtop Automated Pipetting Workstation EosBot® P96
Core FunctionsPlasmid Extraction SpecialistThe OrchestratorBasic Pipetting Specialist
Key Technologies
  • Magnetic Bead-Based Purification

  • 12-Channel Parallel Processing

  • Fully Automated Plasmid Nucleic Acid Extraction

  • Dual Pipetting Module

    (8/24/96 channels)

  • Integrated Multi-Function Modules
    (temp control, shaking, magnetic purification, amplification, QC, etc.)

  • 96-Channel Parallel Processing

  • Full range: 1 μL – 1000 μL

  • Expandable Sealing Function

Application ScenariosPlasmid Extraction、 Transfection‑grade Plasmid Preparation、Gene Therapy Vector ProductionLibrary Prep, PCR Setup, Proteomics Sample Prep & Microbial ScreeningSerial Dilution, Aliquoting, 96-to-384 Replica Plating
<Standalone or integrated — automated "sample in, result out," no human intervention>



2. Two Core Application Scenarios


Scenario 1: High-throughput Screening (SynBio / Enzyme Engineering)


High Throughput Screening Solution



High Throughput Screening Solution

High Throughput Screening Solution

High Throughput Screening Solution

Biomolecule Purification System

TGuide LP12

HT Liquid-handling Workstation EosBot® LH96

Benchtop Automated Pipetting Workstation EosBot® P96

Core FunctionsPlasmid Extraction SpecialistThe OrchestratorBasic Pipetting Specialist
Key Technologies
  • Magnetic Bead-Based Purification

  • 12-Channel Parallel Processing

  • Fully Automated Plasmid Nucleic Acid Extraction

  • Dual Pipetting Module

    (8/24/96 channels)

  • Integrated Multi-Function Modules
    (temp control, shaking, magnetic purification, amplification, QC, etc.)

  • 96-Channel Parallel Processing

  • Full range: 1 μL – 1000 μL

  • Expandable Sealing Function

Application ScenariosPlasmid Extraction、 Transfectiongrade Plasmid Preparation、Gene Therapy Vector ProductionLibrary Prep, PCR Setup, Proteomics Sample Prep & Microbial ScreeningSerial Dilution, Aliquoting, 96-to-384 Replica Plating
<Standalone or integrated — automated "sample in, result out," no human intervention>


<Plasmid Nucleic Acid Extraction and Purification>

The TGuide LP12 Biomolecule Purification System completes the entire workflow from cell pellet to purified plasmid with one-click start, and the extracted product is automatically stored in collection tubes.

<Gene Assembly>

The EosBot® LH96 integrates temperature control and shaking modules to automatically complete reaction setup for restriction ligation, Gibson Assembly, and other reactions.

<Aliquoting & Serial Dilution>

The EosBot® P96 can perform media aliquoting and serial dilution of bacterial cultures.

<Identification & Validation>

Use the EosBot® LH96 to set up PCR or qPCR reactions, followed by sequencing or mass spectrometry sample preparation, with seamless integration to LC-MS.


Scenario 2: High-Throughput Drug Screening (Small Molecule / Antibody / PROTAC)


High Throughput Screening Solution


<Compound Library Management>

The EosBot® P96 enables rapid replica plating and serial dilution from source to working plates (e.g., one stock solution → 8 concentration gradients in a 96-well plate).


<Target-Compound Reaction Assembly>

The EosBot® LH96 processes 384-well plates in parallel, automatically dispensing target proteins, substrates, and detection reagents.


<Signal Detection and Data Output>

Integrates with microplate readers, high-content imagers, and other instruments, with automatic data upload to LIMS.



3. Solving the Three Major Challenges of Traditional Screening


Throughput bottleneck (<500 samples/day)Workstation automates full HTS workflow → throughput boosted ~200× (up to 100K/day)
Low precision (high error in low-volume pipetting, high false ± rates)Full-range liquid handling calibration (1 μL precision CV <2%)
TGuide LP12 automated plasmid extraction – reduces human error
Disconnected workflow (manual transfer, long cycles)Multi‑module integration + unified software orchestration → "Sample in, result out", reducing manual time by ≥70%.


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