| EoSonics® FRAG8 | EoSonics® FRAG96 | |
| Technology | Adaptive Cylindrical Ultrasonic | Adaptive Cylindrical Ultrasonic |
| Dimensions | 417mm(W) × 438mm(D) × 385mm(H) | 660mm(W) × 510mm(D) × 382mm(H) |
| Weight | 25KG | 50KG |
| Throughput | 1 - 8 | 1 - 96 |
| Sample Volume | 15μl ~ 2ml | 15μl ~ 150μl |
| Fragment Sizes | 100bp - 5Kb | 100bp - 5Kb |
| Processing Mode | Single-Row Processing | Single-Row Processing |
| Parameter Settings | 1 Type | 1 - 12 Types |
| Consumables | Standard & Dedicated | Standard & Dedicated |
With an open consumable system, high-precision and efficient shearing performance, and full-scenario application adaptability, the LivoBot Sonicator delivers a more efficient, cost-effective, and stable solution for genomic sequencing sample preparation.
Breaking free from the constraints of instrument-consumable bundling, the system supports open consumables and is directly compatible with standard laboratory consumables such as 8-well strips and PCR plates, significantly reducing annual consumable costs. In addition, a specialized consumable option is available: leveraging a unique structural design that ensures natural, uniform sample distribution within the system, combined with precise acoustic control, the instrument enables direct loading without centrifugation. This streamlined operation marks a key breakthrough in experimental workflow optimization. Open consumables meet the demand for high cost-efficiency, while specialized consumables are tailored for high-end research and clinical applications, offering both flexibility and precision.
Compared to traditional enzymatic fragmentation, the LivoBot Sonicator offers faster processing and greater precision, significantly shortening the pre-sequencing sample preparation cycle and enhancing overall experimental efficiency. It reduces manual operations, minimizes human error, and delivers improved reproducibility and stability, providing reliable support for high-quality sequencing data.
With strong cross-scenario adaptability, the instrument is widely applicable in areas such as clinical genetic testing, life science genomics research, and agricultural crop breeding analysis, providing stable support for the diversified and large-scale application of genomic sequencing technologies.
Enzymatic fragmentation is a biochemical reaction that is easily affected by enzyme activity, reaction conditions, and sample composition. It also exhibits sequence bias, often leading to uneven fragment distribution and poor experimental reproducibility, which can compromise sequencing data quality. In contrast, ultrasonic shearing is a physical fragmentation method that relies on controlled acoustic energy to shear DNA. It is not affected by sequence bias or reaction environment, resulting in more uniform and stable fragment distribution. This effectively avoids the bias and experimental variability associated with enzymatic methods, delivering higher data consistency and result reliability, thereby ensuring superior quality of the sequencing library.
The LivoBot Sonicator features precise acoustic control and a uniform energy field design, ensuring highly consistent fragment distribution within the same batch and across different batches. This effectively reduces experimental variability, providing a more stable and reliable data foundation for sequencing and downstream analyses.
Yes. Ultrasonic shearing involves simple operational steps and minimal pretreatment. With the use of dedicated consumables, samples can be directly loaded onto the instrument without the need for centrifugation or other cumbersome procedures. This allows for seamless integration with automated liquid handling, library preparation, and other automated pipelines, significantly improving overall experimental throughput and automation levels.
